There are no available effective therapies for fatigue associated with MS, and it is unclear whether a successful therapy of MS leads to clinical improvement. Sevim, Serhan KaleaГ„ЕёasГ„В±, Hakan TaГ…Еёdelen, BaharДЇatigue is the most frequent and often debilitating symptom for patients with multiple sclerosis (MS). Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis.

These results suggest that mental time travel impairments in SCZ spectrum disorders and have implications for understanding their cognitive and emotional deficits. Both SCZ patients and SPD proneness individuals generated less positive events than controls. The reduced specificity was mainly manifested in imagining future events. SPD proneness individuals only generated less extended events compared to healthy controls. Results showed that SCZ patients showed significantly reduced specificity in recalling past and imagining future events, they generated less proportion of specific and extended events compared to healthy controls. The Sentence Completion for Events from the Past Test (SCEPT) and the Sentence Completion for Events in the Future Test were used to measure past and future thinking abilities. Thirty-two SCZ patients, 30 SPD proneness individuals, and 33 healthy controls participated in the study. This study aimed to examine episodic past and future thinking in SCZ spectrum disorders including SCZ patients and individuals with schizotypal personality disorder (SPD) proneness who are at risk for developing SCZ. Schizophrenia (SCZ) patients have problems in remembering specific personal experiences in the past and imagining what will happen in the future. Mental time travel refers to the ability to recall past events and to imagine possible future events. Schizophrenia Spectrum Disorders Show Reduced Specificity and Less Positive Events in Mental Time TravelД¬hen, Xing-jie Liu, Lu-lu Cui, Ji-fang Wang, Ya Chen, An-tao Li, Feng-hua Wang, Wei-hong Zheng, Han-feng Gan, Ming-yuan Li, Chun-qiu Shum, David H. Conclusions This work suggests that the cognitive deficits seen in anxiety patients may represent a key component of clinical anxiety, rather than a consequence of threat. Most importantly, these effects were not modulated by threat. In addition, patients showed less WM load-related deactivation in the ventromedial prefrontal cortex and posterior cingulate cortex, which are regions of the default mode network. At the neural level, patients showed less WM load-related activation in the dorsolateral prefrontal cortex, a region critical for cognitive control. Results Behaviorally, patients showed an overall impairment in both accuracy and reaction time compared to controls, independent of threat. controls) and threat on WM load-related BOLD activation. We recorded BOLD activity during the task, and investigated the effect of clinical anxiety ( patients vs. Methods Patients, diagnosed with generalized and/or social anxiety disorder, and controls performed blocks of an N-back WM task during periods of safety and threat of shock.

safety on the neural substrates of WM performance in anxiety patients and healthy controls. Here we distinguish between these hypotheses by determining the effect of shock threat vs. However, it is unclear whether these deficits reflect threat-related processes or symptoms of the disorder. OГўв‚¬в„ўConnell, Katherine Torrisi, Salvatore Letkiewicz, Allison Ernst, Monique Grillon, ChristianД«ackground Anxiety patients exhibit deficits in cognitive tasks that require prefrontal control of attention, including those that tap working memory (WM). Anxiety patients show reduced working memory related dlPFC activation during safety and threatД«alderston, Nicholas L.

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